Reju'vita; is the only food supplement on the world market that combines PQQ with its direct cofactors (CoQ10, alpha-lipoic acid, NADH and astaxanthin) to multiply its ultra-beneficial effects on the metabolism of mitochondria!

Mitochondrial dysfunction is the basis of almost all chronic disease, aging and cell death. Only healthy and functioning mitochondria provide sufficient energy flow for the optimal functioning of various organs and tissues in the human body. Pyrroloquinoline quinone (PQQ) is a molecule involved in the metabolism of the mitochondria (powerhouses of cells, the mitochondria generate energy that feeds the functioning of the metabolism). Its direct implication gives it protective actions of the brain, heart and muscles against degenerative diseases, and, consequently, against cellular aging. In addition, numerous clinical trials have shown that PQQ is a powerful booster for memory and concentration. Recent research also seems to indicate that PQQ can prevent Alzheimer's disease and Parkinson's disease. Reju'vita is the only food supplement on the world market which combines PQQ with its direct cofactors to multiply its ultra beneficial effects on the metabolism of the mitochondria: - Coenzyme Q10 - Alpha lipoic acid - NADH - Astaxanthin The addition of CoQ10 and NADH offers incomparable synergistic benefits! Clinical studies using doses of 10 to 20 milligrams of PQQ have shown improvement in mental processing and memory, but a combination with coenzyme Q10 has been found to be astounding. One study found that PQQ combined with CoQ10 performed better than just one of the nutrients. Reduced nicotinamide adenine dinucleotide (NADH) is the reduced bioactive form of vitamin B3. It is a molecule produced in the mitochondria by the Krebs cycle and, together with coenzyme Q10, contributes very powerful synergistic effects that increase mitochondrial activity and reduce oxidative stress produced in the mitochondria. Besides the fact that CoQ10 and NADH are powerful antioxidants, they also promote the recirculation (catalytic conversion) of other antioxidants. Thus, the association between PQQ, CoQ10 and NADH considerably increases the antioxidant activity in the cell. Both CoQ10 and PQQ are fat soluble, so it is best to take them with meals that contain good fat rather than on an empty stomach. Antioxidant capacity 3 to 4 times more powerful! Alpha-lipoic acid and astaxanthin are powerful antioxidants, they allow the regeneration of non-enzymatic antioxidants like vitamin A, C, E, and coenzyme Q10. Their synergistic effects with PQQ make it possible to potentiate its antioxidant action and increase its recycling. A molecule of PQQ is used as an antioxidant over 20,000 times before it is broken down. Combined with alpha-lipoic acid and astaxanthin, its antioxidant capacity is 3 to 4 times more powerful! Reju'vita increases the density and function of mitochondria PQQ is unique in its ability to improve mitochondrial biogenesis, it is the only nutrient known to date that allows the creation of new healthy mitochondria in aging cells! In addition to improving energy production, PQQ reverses the aging process. In a study at the University of California, Davis, researchers gave PQQ supplements to a small group of men and women and tested the effects 76 hours later. Using blood and urine tests, they found that PQQ improved mitochondrial function and reduced chronic inflammation. The mechanism by which PQQ reduces inflammation, improves mitochondrial function, and stimulates mitochondrial biogenesis is defined by activating the expression of Nrf2, a biological hormone that activates intracellular antioxidants such as superoxide dismutase and catalase. PQQ has also been shown to increase the activity of key transcriptional factors that enable life extension, leading researchers to suggest that PQQ may play a new role in longevity. Indeed, it modulates many signaling pathways, including the mTOR pathway, which plays a role in aging and cancer, helps repair DNA, and therefore increases the lifespan of cells. Additionally, PQQ improves NADH, which is converted to NAD + when food is broken down for energy. When DNA damage is restored, NAD + is consumed. However, if the supply is depleted, the process cannot continue, which is probably the root cause of most of the illnesses we see in the modern world. The effective dose has been estimated to be 0.3 mg PQQ per kilogram of body weight (i.e. 20 mg PQQ for a person weighing 70 kg). Protection of brain cells The ability of PQQ to protect brain cells and their DNA from damage also suggests that it may be a powerful tool in preventing neurodegenerative diseases. Mitochondrial DNA is subject to damage from free radicals and prooxidant molecules. Free radicals are an inevitable artifact of the conversion of energy substrates in food into cellular fuel by mitochondria. PQQ has been shown to protect against this type of damage. In addition, it activates the integrated mechanisms of mitochondrial recovery and replication. In the brain, this results in an overall improvement in neurological function, including cognition, learning and memory, as well as a reduction in the risk of neurodegenerative diseases. Numerous studies have shown that PQQ protects and improves neuronal survival by stimulating the synthesis of nerve growth factor (NGF) in certain glial cells located in the central nervous system. It has also been shown to improve the function of brain cells damaged by beta amyloid (hallmark of Alzheimer's disease) and prevent the formation of alpha-synuclein proteins associated with Parkinson's disease. According to a 2012 study, PQQ may even help prevent nerve cell death in traumatic brain injury. According to the authors of this study, "PQQ may play an important role in healing from head trauma." PQQ - a powerful antioxidant and activator of the immune system Another reason why PQQ is so beneficial is due to its potent antioxidant activity. It is capable of undergoing over 20,000 catalytic conversions in which the antioxidant neutralizes the free radical. In other words, PQQ is a surprisingly potent antioxidant. In comparison, vitamin C can only undergo 4 catalytic conversions before it is depleted. As an antioxidant, PQQ is therefore 5,000 times more efficient than vitamin C. Clinical studies have shown, at doses of 0.2 to 0.3 mg per kg, that PQQ reduces the level of inflammatory biomarkers of C-reactive protein (CRP) and interleukin-6 (IL-6) . PQQ also supports the immune system and its deficiency is associated with immune dysfunction. In a recent study, adding PQQ increased the sensitivity of B and T cells (white blood cells that play a central role in the immune response) to mitogens (proteins that cause cell division or mitosis). PQQ activates the main metabolic switch AMPK The list of potential uses for PQQ is extremely long, as its metabolic effects go far beyond improving mitochondrial function. For example, it helps activate protein kinase, activated by adenosine monophosphate (AMPK), which is an important molecular target for metabolic health. This is because AMPK is an enzyme called a "metabolic master switch" because it plays a crucial role in regulating metabolism. As stated in the journal Natural Medicine: "AMPK causes a cascade of events within cells involved in maintaining energy homeostasis ... AMPK regulates many biological activities that normalize lipid, energy and glucose imbalances." Metabolic syndrome occurs when these pathways, regulated by AMPK, are turned off. Consequences: hyperglycemia, diabetes, lipid metabolism disorders and energy imbalance. AMPK helps coordinate the response to these stressors by shifting energy towards cell repair, maintaining or returning homeostasis, and increasing the chances of survival. The list of health benefits of PQQ is quite long. Although it is found in foods such as natto, parsley, green pepper, spinach, papaya, kiwi and green tea, the doses obtained from the diet are largely insufficient and do not allow for achieve the dosages of functional interest and the related beneficial effects. Reju'vita, from ESE Group laboratories, is the only product on the world market that includes the 4 direct cofactors of PQQ identified in the scientific literature as necessary for its metabolism! In meticulously studied dosages for an optimal effect!

Recommended dosage

2 capsules per day during meals containing good fats or as advised by your healthcare professional.

Contraindications

This dietary supplement should be consumed by adults only, excluding pregnant and breastfeeding women.

Guaranteed without

• Gluten free • Lactose free • Without Conservative agent • Without colouring

Precautions for use

Food supplements are not a substitute for a varied and balanced diet or a healthy lifestyle. Keep out of the reach of children. Do not exceed the recommended daily dose.

Store in a dark, dry place at a temperature between 15 and 25 ° C.

Composition

Composition for 2 capsules: R-alpha lipoic acid 300 mg Haematococcus pluvialis 120 mg including 5% astaxanthin Co-enzyme Q10 (ubiquinone) 100 mg Pyrroloquinoline-quinone (PQQ) 20 mg NADH 20mg

Excipients

No

Ingredients

R-alpha lipoic acid, capsule: pullulan, Haemotococcus pluvialis (5% astaxanthin), coenzyme Q10, pyrroquinoline quinone disodium salt (PQQ), nicotinamide adenine dinucleotide (NADH).